mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-TEO-000mimmun-2179Research ArticleТОЧКА ЗРЕНИЯVIEWPOINTНа свете есть только один фактор некроза опухолейThere exists only one tumor necrosis factorНедоспасовС. А.NedospasovS. A.

Недоспасов Сергей Артурович – доктор биологических наук, профессор, академик РАН, заведующий лабораторией молекулярных механизмов иммунитета ФГБУН «Институт молекулярной биологии имени В.А. Энгельгардта» Российской академии наук; заведующий кафедрой иммунологии биологического факультета ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»; научный руководитель направления «Иммунобиология и биомедицина», Научнотехнологический университет «Сириус»

119991, Москва, ул. Вавилова, 32

Nedospasov Sergei A., PhD, MD (Biology), Professor, Full Member, Russian Academy of Sciences, Head, Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Head, Department of Immunology, Faculty of Biology, Lomonosov Moscow State University; Head of the Section “Immunobiology and Biomedicine”, Sirius University of Science and Technology

119991, Moscow, Vavilov str., 32

sergei.nedospasov@gmail.comФГБУН «Институт молекулярной биологии имени В.А. Энгельгардта» Российской академии наук; ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»; Научно-технологический университет «Сириус»РоссияEngelhardt Institute of Molecular Biology, Russian Academy of Sciences; Lomonosov Moscow State University; Sirius University of Science and TechnologyRussian Federation20201001202122612211224Copyright © Недоспасов С.А., 20212021Недоспасов С.А.Nedospasov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/2179

Фактор некроза опухолей (TNF) – важный провоспалительный и иммунорегуляторный цитокин с несколькими уникальными защитными и гомеостатическими функциями. Поскольку он является медиатором нескольких патологий и участником «цитокинового шторма», то его значение для клинической иммунологии состоит в том, что именно этот цитокин является мишенью широко применяемой антицитокиновой терапии аутоиммунных и воспалительных заболеваний. В научной литературе и многих учебниках TNF часто проходит под обозначением TNFα (альфа), что предполагает существование хотя бы TNFβ (действительно, этим термином в течение примерно 10 лет в 80-90 гг. прошлого века называли лимфотоксин). Однако еще 25 лет назад такое обозначение лимфотоксина было отменено «по научным показаниям». Следовательно, термин «TNF» и по-русски, и по-английски должен использоваться без добавки «альфа». Реагенты на TNFb, продвигаемые различными фирмами, просто вводят исследователей в заблуждение.

Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this cytokine is a target of commonly used anti-cytokine therapy in autoimmune and inflammatory diseases. In scientific literature and textbooks TNF is often goes as “TNFa”, implying the existence of at least TNFβ (indeed, such term was used for about 10 years in 80s and 90s to designate lymphotoxin). However, already 25 years ago such designation of lymphotoxin was cancelled “on scientific grounds”. Therefore, both in Russian and in English the term TNF should be used without “alpha”. Labels of the reagents related to TNFb that are offered by commercial companies are misleading.

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The authors declare that there are no conflicts of interest present.