mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-EOB-2091mimmun-2091Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПовышение уровня BSF-2 в сыворотке крови больных с вирусом гепатита BElevation of BSF-2 Level in Serum of Patients with Hepatitis B Virushttps://orcid.org/0000-0001-8988-5957ДавудАли А.DawoodAli A.

доктор философии Микробиология, лектор, кафедра анатомии

Аль-Джамеа, 1, Мосул

Ph.D. Microbiology, Lecturer, Department of Anatomy

Al-Jameaa, st.1, Mosul

aad@uomosul.edu.iqАльтобьеМахмуд А. А.AltobjeMahmood A. A.

доктор философии Иммунология, доцент, кафедра биологии, Колледж наук

Аль-Джамеа, 1, Мосул

Ph.D. Immunology, Associate Professor, Department of Biology

Al-Jameaa, st.1, Mosul

mahtsbio30@uomosul.edu.iqАль-РрассамЗейад Т.AlrassamZeyad T.

доктор философии Микробиология, преподаватель, кафедра биофизики

Аль-Джамеа, 1, Мосул

Ph.D. Microbiology, Lecturer, Department of Biophysics

Al-Jameaa, st.1, Mosul

dr.zeyadalrassam@uomosul.edu.iqМедицинский колледж Мосульского университетаИракCollege of Medicine, University of MosulIraq2021260220212318794Copyright © Давуд А.А., Альтобье М.А., Аль-Ррассам З.Т., 20212021Давуд А.А., Альтобье М.А., Аль-Ррассам З.Т.Dawood A.A., Altobje M.A., Alrassam Z.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/2091

Справочная информация: Гепатит В - основная инфекция пораженной печени человека. Воспаление печени, вызванное вирусами гепатита, может привести к циррозу и гепатоцеллюлярной карциноме. Фактор стимуляции В-клеток 2 (BSF-2) является одним из цитокинов, влияющих на регуляцию и дифференциацию иммунного ответа человека. Цель: этот отчет направлен на оценку уровней BSF-2, GPT и GOT в сыворотке крови пациентов с различными стадиями гепатита B по сравнению со здоровым контролем. Методы. В этом исследовании участвовало 52 пациента, предположительно с острыми и хроническими заболеваниями, у которых обнаружен HBsAg. BSF-2 был обнаружен с помощью анализа ELISA. Биохимические показатели определяли с помощью комплектов автоматического анализатора. Для статистического анализа использовалось программное обеспечение SPSS версии 16. Результаты. У пациентов с острым гепатитом В уровень BSF-2 повышен больше, чем при хроническом гепатите B. Уровни GPT и GOT повышены в группе острого гепатита больше, чем в группе хронического гепатита. Мы сообщили о значительном значении между уровнями BSF-2, GOT и GPT. Мы не оценивали связь между возрастом пациента и группами случаев гепатита. Заключение: наши данные подтверждают повышение уровня BSF-2 при повышении уровня GOT больше, чем уровень GPT при остром гепатите B. Уровни BSF-2, GPT и GOT варьируются в зависимости от течения острого и хронического HBV. Мы предположили, что повышение уровня BSF-2 указывает на повреждение печени у пациентов с острым HBV.

Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.

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The authors declare that there are no conflicts of interest present.