mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-CEO-1990mimmun-1990Research ArticleМАТЕРИАЛЫ ФОРУМА "ДНИ ИММУНОЛОГИИ В СПБ" 2021СРАВНИТЕЛЬНАЯ ЭФФЕКТИВНОСТЬ РАЗЛИЧНЫХ СХЕМ ИММУНОРЕАБИЛИТАЦИИ ПРИ БЕСПЛОДИИ ТРУБНОПЕРИТОНЕАЛЬНОГО ГЕНЕЗАCOMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESISПоО. Б.Ж.PoO. B.J.

ассистент кафедры акушерства и гинекологии,

305041, г. Курск, ул. К. Маркса, 3

Assistant Professor, Department of Obstetrics and Gynecology, 

305041, Kursk, K. Marx street, 3

sha_po@inbox.ruКонопляА. А.KonoplyaA. A.

д.м.н., доцент кафедры акушерства и гинекологии,

305041, г. Курск, ул. К. Маркса, 3

PhD, MD (Medicine), Associate Professor, Department of Obstetrics and Gynecology, 

305041, Kursk, K. Marx street, 3

МедведеваИ. Н.MedvedevaI. N.

к.м.н., доцент кафедры акушерства и гинекологии,

305041, г. Курск, ул. К. Маркса, 3

PhD (Medicine), Associate Professor, Department of Obstetrics and Gynecology,

305041, Kursk, K. Marx street, 3

ФГБОУ ВО «Курский государственный медицинский университет»РоссияKursk State Medical UniversityRussian Federation202107102021234927932Copyright © По О.Б., Конопля А.А., Медведева И.Н., 20212021По О.Б., Конопля А.А., Медведева И.Н.Po O.B., Konoplya A.A., Medvedeva I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1990

Целью исследования явилось сравнение эффективности различных схем фармакотерапии при бесплодии трубно-перитонеального генеза. Под постоянным наблюдением находились 96 пациенток, направленных в стационар для проведения диагностической лапароскопии по поводу бесплодия трубно-перитонеального генеза, разделенных поровну на 4 группы в зависимости от способов фармакологического лечения: 1-я группа получала базовую фармакотерапию (БФТ) после эндоскопического операционного вмешательства (антибактериальная, притивогрибковая, витаминотерапия). Пациентки 2-4-й групп, кроме БФТ, соответственно получали гепон, циклоферон или лавомакс. Контрольная группа была сформирована из 38 гинекологически здоровых женщин. Лабораторное обследование осуществляли в течение 24 часов после операции и на 30-е сутки после БФТ. В вагинально-цервикальном смыве и в плазме крови оценивали активность процессов перекисного окисления липидов, состояние антиоксидантной системы, выявляли уровень стабильных метаболитов оксида азота, неоптерина, С-реактивного белка, цитокинов (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), иммуноглобулинов (IgМ, IgG, IgА, sIgA), компонентов системы комплемента (С3, С4, С5, С5А), фагоцитарную и кислородзависимую активность полиморфноядерных лейкоцитов крови. Установлено , что применение в БФТ препаратов с иммуномодулирующей и антивирусной активностью по степени возрастания эффективности в коррекции иммунометаболических лабораторных параметров на системном и местном уровне при бесплодии трубно-перитонеального генеза представляет собой следующую последовательность: базовая фармакотерапия < базовая фармакотерапия + гепон < базовая фармакотерапия + циклоферон < базовая фармакотерапия + лавомакс. 

The study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BPT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). Patients of groups 2-4, in addition to BPT, received Hepon, Cycloferon or Lavomax, respectively. The control group consisted of 38 gynecologically healthy women. Laboratory examination was performed within 24 hours after the operation and on the 30th day after BPT. Vaginocervical lavage and plasma were assayed for the activity of lipid peroxidation processes, the state of the antioxidant system, the level of stable nitric oxide metabolites, neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA, sIgA), components of the complement system (C3, C4, C5, C5А), phagocytic and oxygen-dependent activity of polymorphonuclear leukocytes. It was established that the use of immunomodulatory and antiviral activity medication with BPT according to the degree of increasing efficiency in the correction of immunometabolic laboratory parameters at the systemic and local level in infertility of tuboperitoneal genesis is as the following sequence: basic pharmacotherapy < basic pharmacotherapy + Hepon < basic pharmacotherapy + Cycloferon < basic pharmacotherapy + Lavomax. 

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The authors declare that there are no conflicts of interest present.