mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-1-27-34mimmun-19Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИНТЕНСИВНОСТЬ ПРОЦЕССОВ АПОПТОЗА И ПРОЛИФЕРАЦИИ ЛИМФОЦИТОВ В УСЛОВИЯХ ДИСЛИПИДЕМИИ ПРИ РАННИХ ФОРМАХ ХРОНИЧЕСКОЙ ИШЕМИИ МОЗГАINTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIAЗурочкаА. В.ZurochkaA. V.

д.м.н., профессор, ФГБУН«Институт иммунологии и физиологии» УрО РАН

PhD, MD (Medicine), Professor,Research Institute of Immunology and Physiology,Russian Academy of Sciences, Ural Branch

v_zurochka@mail.ruДавыдоваЕ. В.DavydovaE. V.

к.м.н., старший преподавателькафедры патофизиологии ГБОУ ВПО «Южно-Уральский государственный медицинскийуниверситет», г. Челябинск

PhD (Medicine), Senior Lecturer,Department of Pathophysiology, South Ural StateMedical University, Chelyabinsk

v_zurochka@mail.ruАльтманД. А.AltmanD. A.

профессор кафедрыневрологии ГБОУ ВПО «Южно-Уральскийгосударственный медицинский университет»,г. Челябинск

v_zurochka@mail.ruФГБУН «Институт иммунологии и физиологии» УрО РАН, г. ЕкатеринбургРоссияResearch Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, EkaterinburgRussian FederationГБОУ ВПО «Южно-Уральский государственный медицинский университет», г. ЧелябинскРоссияSouth Ural State Medical University, ChelyabinskRussian Federation2014050720141612734Copyright © Зурочка А.В., Давыдова Е.В., Альтман Д.А., 20142014Зурочка А.В., Давыдова Е.В., Альтман Д.А.Zurochka A.V., Davydova E.V., Altman D.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/19

Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis.

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The authors declare that there are no conflicts of interest present.