mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2008-4-5-347-352mimmun-187Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРОЛЬ ПРОАНГИОГЕННЫХ И АНТИАНГИОГЕННЫХ ФАКТОРОВ В РАЗВИТИИ ПЛАЦЕНТЫROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENTСоколовД. И.SokolovD. I.

199034, Санкт-Петербург, Менделеевская линия, 3

corbie@hotmail.ruКолобовА. В.KolobovA. V.corbie@hotmail.ruЛесничияМ. В.LesnichijaM. V.corbie@hotmail.ruКостючекИ. Н.KostiouchekI. N.corbie@hotmail.ruБоляК. В.BolyaK. V.corbie@hotmail.ruАржановаО. Н.ArzhanovaO. N.corbie@hotmail.ruКветнойИ. М.KvetnoyI. M.corbie@hotmail.ruСельковС. А.SelkovS. A.corbie@hotmail.ruГУ НИИ акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-ПетербургRussian Federation200817072014104-5347352Copyright © Соколов Д.И., Колобов А.В., Лесничия М.В., Костючек И.Н., Боля К.В., Аржанова О.Н., Кветной И.М., Сельков С.А., 20142014Соколов Д.И., Колобов А.В., Лесничия М.В., Костючек И.Н., Боля К.В., Аржанова О.Н., Кветной И.М., Сельков С.А.Sokolov D.I., Kolobov A.V., Lesnichija M.V., Kostiouchek I.N., Bolya K.V., Arzhanova O.N., Kvetnoy I.M., Selkov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/187

Резюме. Сосудистая сеть плаценты обладает пластичностью и динамически изменяется в течение беременности. Развитие плаценты находится под контролем различных цитокинов и ростовых факторов, соотношение которых изменяется в процессе беременности. Целью настоящего исследования была оценка экспрессии и секреции тканью плаценты проангиогенных и антиангиогенных факторов на ранних (первый триместр) и поздних (третий триместр) этапах физиологически протекающей беременности. Установлено что на ранних этапах развития, по сравнению c третьим триместром беременности, ткань плаценты продуцировала большее количество проангиогенных факторов VEGF, PDGF, IL-8, MMP-2. К третьему триместру снижалась экспрессия VEGF-R3 и секреция клетками плаценты bFGF, но увеличивалась продукция ангиогенина. Отмечено снижение продукции антиангиогенных факторов TSP-1 и TGFβ и экспрессии рецепторов TGFβ-R1, CD105 тканью плаценты к третьему триместру беременности. В непрерывно развивающейся ткани плаценты наблюдается преобладание ангиогенных факторов, в то же время антиангиогенные факторы играют существенную роль в формировании ткани плаценты, обеспечивая торможение ангиогенеза.

Abstract. Vascular network of placenta exhibits plasticity, and undergoes various dynamic changes in the course of pregnancy. Placental development is controlled by various cytokines and growth factors, and their ratios show strong fluctuations during pregnancy. The purpose of present study was to evaluate expression and secretion of proangiogenic and antiangiogenic factors by placental tissue at early stages (1st trimester) and late terms (3rd trimester) of normally proceeding pregnancy. It was established that at earlier stages (1st trimester), placental tissue produced larger quantities of proangiogenic factors (VEGF, PDGF, IL-8, MMP-2), in comparison to the 3rd trimester of pregnancy. By the 3rd trimester, VEGF-R3 expression and bFGF secretion by placental cells was also decreased, accompanied by increased production of angiogenin. Moreover, a suppressed production of antiangiogenic factors TSP-1 and TGFβ and expression of TGFβ-R1, CD105 receptors by placenta tissue was registered by the 3rd trimester of pregnancy. In permanently evolving placental tissue, an excess of angiogenic factors is observed. Meanwhile, antiangiogenic factors also seem to play an essential role in formation of placental tissue, thus providing angiogenesis inhibition.

The study was supported by Presidential grants of Russian Federation N НШ-1066.2008.7, МК-1355.2007.7, and by a grant of Russian Foundation for Basic Research № 070400155. (Med. Immunol., vol. 10, N 4-5, pp 347-352).

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The authors declare that there are no conflicts of interest present.