mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-CAI-1866mimmun-1866Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESКлинико-иммунологическая характеристика естественного течения ВИЧ-инфекции на ранних сроках инфицированияClinical and immunological characteristic of natural course at the early stages of HIV infectionhttps://orcid.org/0000-0003-4300-4602МанаповаЭ. Р.ManapovaE. R.

Манапова Эльвира Равилевна - д.м.н., доцент кафедры инфекционных болезней

420012, Республика Татарстан, г. Казань, ул. Бутлерова, 4Teл.: 8 (917) 294-66-63

Manapova Elvira R., PhD, MD (Medicine), Associate Professor, of Department of Infectious Diseases

420012, Republic of Tatarstan, Kazan, Butlerov str., 49Phone: 7 (917) 294-66-63

elveram@yandex.ruhttps://orcid.org/0000-0003-4333-6316ФазыловВ. Х.FazylovV. Kh.

д.м.н., профессор кафедры поликлинической терапии и общей врачебной практики

г. Казань

PhD, MD (Medicine), Professor, Department of Outpatient Therapy and General Medical Practice

Kazan

fazylov47@inbox.ruhttps://orcid.org/0000-0001-6032-2456БешимовА. Т.BeshimovA. T.

к.м.н., заместитель главного врача по поликлинической работе

г. Казань

PhD (Medicine), Deputy Chief Physician of Outpatient Clinic

Kazan

beshimov@rambler.ruФГБОУ ВО «Казанский государственный медицинский университет» Министерства здравоохранения РФРоссияKazan State Medical UniversityRussian FederationГАУЗ «Республиканский центр по профилактике и борьбе со СПИД и инфекционными заболеваниями» Министерства здравоохранения Республики Татарстан»РоссияRepublican Center for the Prevention and Control of AIDS and Infectious DiseasesRussian Federation202020052020223519526Copyright © Манапова Э.Р., Фазылов В.Х., Бешимов А.Т., 20202020Манапова Э.Р., Фазылов В.Х., Бешимов А.Т.Manapova E.R., Fazylov V.K., Beshimov A.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1866

Инфекция на ранних сроках индуцирует наиболее мощные реакции со стороны иммунной системы. Проанализированы 137 клинических историй пациентов с ВИЧ-инфекцией и ВГС/ВИЧ-инфицированных на ранних сроках инфицирования ВИЧ. Группа из 45 пациентов на ранних сроках инфицирования ВИЧ – из них 25 ВГС/ВИЧ-инфицированных (первая группа) и 20 с ВИЧ-моноинфекцией (вторая группа), длительность инфицирования составляла менее 1 года (при ИФА (+), иммуноблот становился положительным в среднем в течение 5,5±0,6 мес.). Для сравнительного анализа была обследована группа естественного течения – 43 пациента с сочетанной ВГС/ВИЧ-инфекцией (третья группа) и 49 с ВИЧ-моноинфекцией (четвертая группа) с длительностью инфицирования ВИЧ 4,4±0,21 года; в группе здоровых было 52 человека. Цель – провести сравнительную характеристику клинического течения и иммунологических особенностей c ранних сроков инфицирования у пациентов с сочетанной ВГС/ВИЧ и ВИЧ-инфекцией. Результаты: у ВГС/ВИЧ-инфицированных с ранних сроков инфицирования на фоне более выраженного угнетения клеточного иммунитета и повышенной вирусной нагрузки РНК ВИЧ по сравнению с данными при ВИЧ-инфекции в клинической картине преобладали гнойно-воспалительные, грибковые поражения и вторичные заболевания.

An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.

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The authors declare that there are no conflicts of interest present.