mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2019-3-379-396mimmun-1812Research ArticleОБЗОРЫREVIEWSПЛОТНОСТЬ ЭКСПРЕССИИ РЕЦЕПТОРОВ К ИММУНОРЕГУЛЯТОРНЫМ МЕДИАТОРАМ КАК МОДУЛИРУЮЩИЙ КОМПОНЕНТ БИОЛОГИЧЕСКИХ ЭФФЕКТОВ МЕДИАТОРОВ НА КЛЕТКУ (ЧАСТЬ 2)EXPRESSION DENSITY OF RECEPTORS FOR IMMUNOREGULATORY MEDIATORS AS A MODULATORY COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS UPON CELLS (PART 2)СенниковС. В.SennikovS. V.

д.м.н., профессор, заведующий лабораторией молекулярной иммунологии

630099, г. Новосибирск, ул. Ядринцевская, 14. Тел.: 8 (383) 222-19-10.

PhD, MD (Medicine), Professor, Head, Laboratory of Molecular Immunology

630099 Novosibirsk, Yadrintsevskaya str., 14. Phone: 7 (383) 222-19-10.

sennikovsv@gmail.comАльшевскаяА. А.AlshevskayaA. A.

к.м.н., научный сотрудник лаборатории молекулярной иммунологии 

г. Новосибирск

PhD (Medicine), Research Associate, Laboratory of Molecular Immunology

Novosibirsk

ЖуковаЮ. В.ZhukovaYu. V.

аспирант лаборатории молекулярной иммунологии 

г. Новосибирск

Postgraduate Student, Laboratory of Molecular Immunology

Novosibirsk

БеломестноваИ. А.BelomestnovaI. A.

студентка лаборатории молекулярной иммунологии 

г. Новосибирск

Student, Laboratory of Molecular Immunology

Novosibirsk

КарауловА. В.KaraulovA. V.

д.м.н., профессор, заведующий кафедрой клинической иммунологии и аллергологии 

г. Москва

PhD, MD (Medicine), Professor, Head, Department of Clinical Immunology and Allergology

Moscow

ЛопатниковаЮ. А.LopatnikovaYu. A.

к.м.н., старший научный сотрудник лаборатории молекулярной иммунологии 

г. Новосибирск

PhD (Medicine), Senior Research Associate, Laboratory of Molecular Immunology

Novosibirsk

ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»; ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»РоссияResearch Institute of Fundamental and Clinical Immunology; Novosibirsk State UniversityRussian FederationФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»РоссияResearch Institute of Fundamental and Clinical ImmunologyRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФ (Сеченовский университет)РоссияFirst Moscow I. Sechenov State Medical UniversityRussian Federation201911072019213379396Copyright © Сенников С.В., Альшевская А.А., Жукова Ю.В., Беломестнова И.А., Караулов А.В., Лопатникова Ю.А., 20192019Сенников С.В., Альшевская А.А., Жукова Ю.В., Беломестнова И.А., Караулов А.В., Лопатникова Ю.А.Sennikov S.V., Alshevskaya A.A., Zhukova Y.V., Belomestnova I.A., Karaulov A.V., Lopatnikova Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1812

В обзоре обобщены последние мировые научные данные о роли рецепторов к иммуномедиаторам в регуляции биологических эффектов, оказываемых на клетки. Для основных классов регуляторов иммунной системы (интерлейкинов, интерферонов, факторов роста и факторов некроза опухоли) представлены варианты участия рецепторов как компонентов взаимодействия цитокин/ клетка на примере in vitro и in vivo исследований. Показана способность показателей экспрессии рецепторов менять характер и тип данного взаимодействия. Проанализированы данные об участии рецепторов к регуляторным молекулам в развитии иммуноопосредованных заболеваний различного генеза. Продемонстрировано, что изменение уровня экспрессии рецепторов имеет большое значение в оценке функционального ответа клетки на медиатор и в развитии патологических состояний. В исследованиях подтверждены данные о влиянии плотности рецепторов на процессы пролиферации и апоптоза, а также обменные процессы, что является триггером в развитии аутоиммунных, онкологических и дистрофических заболеваний. Для всех рассмотренных классов регуляторных молекул характерным является изменение плотности экспрессии рецепторов как одного из ключевых моментов регулирования функциональной активности клеток. Таким образом, изучение уровня экспрессии рецепторов на мембране клеток является важным в понимании патогенеза, а изменение уровня экспрессии может рассматриваться как терапевтическая мишень в лечении различных заболеваний.

The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.

цитокинырецепторыиммунорегуляцияиммунопатологияиммунотерапияфакторы ростаинтерлейкиныинтерфероныфактор некроза опухолиcytokinesreceptorsimmunoregulationimmunopathologyimmunotherapygrowth factorsinterleukinsinterferonstumor necrosis factorРабота поддержана грантом Сеченовского университета 2018.ReferencesСенников С.В., Альшевская А.А., Жукова Ю.В., Беломестнова И.А., Караулов А.В., Лопатникова Ю.А. Плотность экспрессии рецепторов к иммунорегуляторным медиаторам как модулирующий компонент биологических эффектов медиаторов на клетку (часть 1)// Медицинская иммунология, 2019. Т. 21, № 2. С. 209-220. doi: 10.15789/1563-0625-2019-2-209-220.Sennikov S.V., Alshevskaya A.A., Zhukova Yu.V., Belomestnova I.A., Karaulov A.V., Lopatnikova Yu.A. Expression Density of receptors for immunoregulatory mediators as a modulatory component of biological effects of mediators upon cells (part 1). 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The authors declare that there are no conflicts of interest present.