mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-EOH-1728mimmun-1728Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОценка фенотипов гаптоглобина при остром инфаркте миокарда (ОИМ) и их ассоциация с некоторыми факторами рискаEvaluation of haptoglobin phenotypes in acute myocardial infarction (AMI) and their association with some risk factorsХазеиХ. А.KhazaeiH. A.

Хазеи Хосейн Али, научный центр клинической иммунологии

Захедан

Khazaei Hossein Ali, Clinical Immunology Research Center

Zahedan

 

ХаратиХ.HaratiH.

Хони Харати, отдел сердечно-сосудистых заболеваний

пл. Хесаби, ЗахеданТел.: +9 (8912) 378-57-21Факс: +9 (8541) 342-57-40

Harati Hony, Department of Cardiovascular Diseases

Hesabi Sq, ZahedanPhone: +9 (8912) 378-57-21Fax: +9 (8541) 342-57-40

Harati_honey@yahoo.comБолуриА.BolouriA.

Болури Ахмад, отдел сердечно-сосудистых заболеваний

Захедан

Bolouri Ahmad, Department of Cardiovascular Diseases

Zahedan

НахеиА.NakhaeiA.

Нахеи Алиреза, отдел биохимии

Захедан

Nakhaei Alireza, Department of Biochemistry

Zahedan

МохаммадиМ.MohammadiM.

Мохаммади Махди, отдел биостатистики и научный центр охраны здоровья

Захедан

Mohammadi Mahdi, Department of Biostatistics and Health Promotion Research Center

Zahedan

НазариФ.NazariF.

Назари Фарзад, научный центр иммунодефицитов, Педиатрический медицинский центр

Тегеран

Nazari Farzad, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center

Tehran

FarzadNazari91@gmail.comНоураМ.NouraM.

Нура Мехраниз, отдел биохимии

Захедан

Noura Mehrangeez, Department of Biochemistry

Zahedan

ХазеиА.KhazaeiA.

Хазеи Амин

Захедан

Khazaei Amin

Zahedan

ХазеиБ.KhazaeiB.

Хазеи Баман

Захедан

Khazaei Bahman

Zahedan

ДадрасО.DadrasO.

Дадрас Амид

Захедан

Dadras Omid

Zahedan

АтабакиМ.AtabakiM.

Атабаки Махди, научный центр клинической иммунологии

Захедан

Atabaki Mahdi, Clinical Immunology Research Center

Zahedan

КалатиМ.KalatiV.

Калафи Ахса

Захедан

Kalati Mahsa

Zahedan

Университет медицинских наукИранZahedan University of Medical SciencesIslamic Republic of IranУниверситет медицинских наукИранTehran University of Medical SciencesIslamic Republic of Iran202020052020223527532Copyright © Хазеи Х.А., Харати Х., Болури А., Нахеи А., Мохаммади М., Назари Ф., Ноура М., Хазеи А., Хазеи Б., Дадрас О., Атабаки М., Калати М., 20202020Хазеи Х.А., Харати Х., Болури А., Нахеи А., Мохаммади М., Назари Ф., Ноура М., Хазеи А., Хазеи Б., Дадрас О., Атабаки М., Калати М.Khazaei H.A., Harati H., Bolouri A., Nakhaei A., Mohammadi M., Nazari F., Noura M., Khazaei A., Khazaei B., Dadras O., Atabaki M., Kalati V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1728

Острый инфаркт миокарда (ОИМ) – одно из самых частых сердечно-сосудистых осложнений со сложным патогенезом, с вовлечением воспалительных маркеров в этиологию болезни. Целью данного исследования было исследование фенотипов гаптоглобина и их ассоциации с некоторыми факторами риска у больных с анамнезом ОИМ. Тип исследования: 120 пациентов направленных в отделение неотложной помощи госпиталя Амир Али г. Захедан (Иран) были включены в поперечно-срезовое исследование с контролем. 120 нормальных лиц были подобраны в качестве контрольной группы. Сыворотку получали из рутинных образцов крови, взятых для диагностики и применяли для определения распределения фенотипов гаптоглобина путем электрофореза. Проводили анализ различий по фенотипам среди пациентов и контрольной группы, используя тест χ2 и программу SPSS. Обнаружена высокая частота фенотипа Hp2-2 гаптоглобина у пациентов и здорового контроля (соответственно, 62,5 и 58,3%). Значимая статистическая корреляция между высокой частотой фенотипа Hp2-2 гаптоглобина и острым инфарктом миокарда (ОИМ) не была выявлена (p = 0,484). В то же время высокая частота фенотипов Hp1-1 и Hp2-2 была ассоциирована с гиперлипидемией и гипертонией, соответственно (p = 0,01 и 0,04). Наши результаты показали высокую частоту фенотипа гаптоглобулина Hp2-2 у больных, а также здоровых лиц в популяции. Высокая частота Hp1-1 и Hp2-2 были ассоциированы у пациентов с инфарктом миокарда с гиперлипидемией и гипертензией соответственно. Таким образом, эти фенотипы у пациентов с ОИМ могут модулировать воспалительный ответ в сочетании с гиперлипидемией и гипертензией.

Acute myocardial infarction (AMI) is one of the most common cardiovascular complications with a complex pathogenesis where inflammatory markers are involved in disease etiology. The aim of this study was to investigate haptoglobin phenotypes and their association with some risk factors in patients with a history of AMI. 120 patients who were referred to the emergency department of Amir Al Momenin hospital of Zahedan city, Zahedan-Iran were recruited in a cross-sectional case control study. 120 normal individuals were also chosen as controls for this study. Serum was isolated from routine bloods taken for diagnostic tests and used to determine haptoglobin phenotype distribution by electrophoresis. Phenotype differences as percent of phenotype frequency in patient and control groups were analysed using the χ2 test and SPSS software. A high frequency of serum Hp2-2 haptoglobin phenotype in patients and healthy control were found (62.5% and 58.3% respectively). A meaningful statistical correlation between high frequency of Hp2-2 haptoglobin phenotype and AMI was not found (p value = 0.484). Whereas high frequency of Hp1-1 and HP2-2 phenotypes was associated with hyperlipidemia and hypertension respectively (p value = 0.01 and 0.04). Our results showed that there was a high frequency of Hp2-2 haptoglobin phenotype in patients as well as healthy controls in the population studies. High frequencies of Hp1-1and Hp2-2 phenotypes were associated with AMI in patients with hyperlipidemia and hypertension respectively. Thus these phenotypes in AMI patients may modulate the inflammatory response in combination with hyperlipidemia and hypertension.

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The authors declare that there are no conflicts of interest present.