mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2019-4-587-594mimmun-1688Research ArticleОБЗОРЫREVIEWSРОЛЬ Т-РЕГУЛЯТОРНЫХ КЛЕТОК В ПРОГРЕССИРОВАНИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCERПоповС. В.PopovS. V.

д.м.н., профессор, врач-уролог, кафедра общей врачебной практики

PhD, MD (Medicine), Professor, Clinical Urologist, Department of General Medical Practice

Moscow

СтуровН. В.SturovN. V.

к.м.н., доцент, заведующий кафедрой общей врачебной практики Медицинского института

PhD (Medicine), Head, Department of General Medical Practice

Moscow

ВоробьевН. В.VorobyevN. V.

к.м.н., заведующий урологическим отделением отдела опухолей репродуктивных и мочевыводящих органов МНИОИ им. П.А. Герцена

 

ХайдуковСергей ВалерьевичKhaidukovS. V.

д.б.н., старший научный сотрудник отдела химической биологии гликанов и липидов

117997, Россия, Москва, ГСП-7, ул. Миклухо-Маклая, 16/10

Тел.: 8 (985) 923-41-62

PhD, MD (Biology), Senior Research Associate, Department of Chemical Biology of Glycans and Lipids

117997, Russian Federation, Moscow, GSP-7, Miklukho-Maklay str., 16/10+7 (985) 923-41-62

khsergey54@mail.ruФГАОУ ВО «Российский университет дружбы народов»РоссияMedical Institute at the Russian Peoples’ Friendship UniversityRussian FederationФГБУ ««Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения РФРоссияP. Herzen Research Institute of Oncology, National Medical Research Radiological CenterRussian FederationФГБУН «Институт биоорганической химии имени академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наукРоссияM. Shemyakin and Yu. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesRussian Federation201911032019214препринт587594Copyright © Попов С.В., Стуров Н.В., Воробьев Н.В., Хайдуков С.В., 20192019Попов С.В., Стуров Н.В., Воробьев Н.В., Хайдуков С.В.Popov S.V., Sturov N.V., Vorobyev N.V., Khaidukov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1688

The existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations from the tumor microenvironment has shown that the number of CD4+Tregs is associated with inferior clinical prognosis. In particular, each additional CD4+Treg cell has been shown to cause a statistically significant increase in prostate cancer mortality by 12%, regardless of other clinical factors. There are several possible explanations for the increased infiltration of prostate cancer tissue with regulatory T cells. Firstly, malignant cells or tumor-associated macrophages are capable of secreting chemokine CCL22, which has an affinity for the CCR4 receptor expressed on Treg cells. Secondly, cytokines secreted by prostate tumors, such as TGF-β, may regulate the FoxP3 expression, thus expanding the Treg population. TGF-β, in turn, is a multifunctional cytokine that promotes survival and proliferation of transformed cells, including prostate epithelium, as evidenced by increased amounts in the patients with metastatic disease.

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The authors declare that there are no conflicts of interest present.