mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2018-6-807-814mimmun-1665Research ArticleОБЗОРЫREVIEWSРОЛЬ CD200/CD200R-ВЗАИМОДЕЙСТВИЯ В ФОРМИРОВАНИИ ИММУНОЛОГИЧЕСКОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ И БЕРЕМЕННОСТИTHE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCYАрефьеваА. С.ArefievaA. S.

научный сотрудник лаборатории клинической иммунологии

117997, Россия, Москва, ул. Академика Опарина, 4.Тел.: 8 (495) 438-11-83

Research Associate, Laboratory of Clinical Immunology

117997, Russian Federation, Moscow, Acad. Oparin str., 4.Phone: 7 (495) 438-11-83

a_arefeva@oparina4.ruБабаянА. А.BabayanA. A.

к.м.н., врач акушер-гинеколог, отделение вспомогательных технологий в лечении бесплодия

PhD (Medicine), Obstetrician-Gynecologist, Department of Assisted Technologies in Treatment of Infertility

СтепановаЕ. О.StepanovaE. O.

младший научный сотрудник лаборатории клинической иммунологии

Junior Research Associate, Laboratory of Clinical Immunology

ДонцоваТ. В.DontsovaT. V.

аспирант, отделение вспомогательных технологий в лечении бесплодия

Postgraduate Student, Department of Assisted Technologies in Treatment of Infertility

ПавловичС. В.PavlovichS. V.

к.м.н., доцент, врач акушер-гинеколог, 1-е акушерское отделение патологии беременности

PhD (Medicine), Associate Professor, Obstetrician-Gynecologist, Department of Maternal-Fetal Medicine

КречетоваЛ. В.KrechetovaL. V.

к.м.н., заведующая лабораторией клинической иммунологии

PhD (Medicine), Head, Laboratory of Clinical Immunology

НиколаеваМ. А.NikolaevaM. A.

д.б.н., ведущий научный сотрудник лаборатории клинической иммунологии

PhD, MD (Biology), Leading Research Associate, Laboratory of Clinical Immunology

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени В.И. Кулакова»РоссияNational Medical Research Center for Obstetrics, Gynecology and PerinatologyRussian Federation201813122018206807814Copyright © Арефьева А.С., Бабаян А.А., Степанова Е.О., Донцова Т.В., Павлович С.В., Кречетова Л.В., Николаева М.А., 20182018Арефьева А.С., Бабаян А.А., Степанова Е.О., Донцова Т.В., Павлович С.В., Кречетова Л.В., Николаева М.А.Arefieva A.S., Babayan A.A., Stepanova E.O., Dontsova T.V., Pavlovich S.V., Krechetova L.V., Nikolaeva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1665

Трансмембранный иммунорегуляторный гликопротеин CD200 принадлежит к семейству иммуноглобулинов и широко представлен на множестве типов клеток, в то время как его сходный по структуре рецептор CD200R в основном экспрессируется на миелоидных и лимфоидных клетках. Иммуномодуляторная роль взаимодействия молекул CD200 и CD200R заключается в активации внутриклеточного ингибиторного каскада реакций, приводя к супрессии эффекторных иммунных клеток и подавляя воспалительный процесс. Так, активация CD200R стимулирует дифференцировку наивных Т-клеток в регуляторные, повышает активность фермента индоламин2,3-диоксигеназы и усиливает синтез цитокинов IL-10 и TGF-β, способствуя формированию Th2-зависимого противовоспалительного окружения. Данные процессы являются ключевыми в обеспечении иммунологической толерантности и необходимы для контроля развития аутоиммунных процессов, гиперчувствительности, приживления трансплантированных органов и тканей, а также при беременности для защиты полуаллогенного плода, несущего чужеродные антигены отца, от отторжения. Толерогенный потенциал взаимодействия молекул CD200 и CD200R может быть эффективно использован при лечении множества заболеваний (например, болезни Альцгеймера, ревматоидного артрита, аллергии). В данном обзоре большое внимание уделено роли CD200/CD200R-взаимодействия в стимуляции приживления аллотрансплантата и предотвращения спонтанного выкидыша. На основании многочисленных исследований можно утверждать, что в основе обоих процессов лежат сходные иммунологические механизмы, одним из ключевых участников которых является молекула CD200.

The transmembrane CD200 glycoprotein belongs to the immunoglobulin family and it is widely represented on a variety of cell types, while its structurally similar CD200R receptor is expressed, mainly, on myeloid and lymphoid cells. An immunomodulatory role of CD200 and CD200R interaction is to activate the intracellular inhibitory cascade of reactions, leading to suppression of effector immune cells and attenuation of the inflammatory process. Thus, the CD200R activation stimulates the differentiation of naive T cells to regulatory T cells, increasing the indolamine 2,3-dioxygenase activity, and enhances the synthesis of IL-10 and TGF-β cytokines, contributing to development of a Th2-dependent anti-inflammatory environment. These immune regulatory events provide the development of immune tolerance and are required for controlling the development of autoimmune processes, hypersensitivity, engraftment of transplanted organs and tissues, as well as protecting the fetus from spontaneous abortion. Tolerogenic potential of interaction between CD200 and CD200R molecules can be effectively used for treatment of various diseases (e.g., Alzheimer’s, rheumatoid arthritis, allergies). In this review, we will address the role of CD200/CD200R interactions in stimulating the post-transplant engraftment and protecting a fetus from spontaneous abortion. Many in vivo and in vitro studies have suggested a key role of CD200/CD200R interaction in immune maintenance of both processes. 

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The authors declare that there are no conflicts of interest present.