mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2018-5-747-752mimmun-1643Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSДИНАМИЧЕСКИЕ ИЗМЕНЕНИЯ ГРАНУЛИЗИНА И КАТЕЛИЦИДИНА У ДЕТЕЙ И ПОДРОСТКОВ, БОЛЬНЫХ РАЗЛИЧНЫМИ ФОРМАМИ ТУБЕРКУЛЕЗА ОРГАНОВ ДЫХАНИЯDYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSISАвербахМ. М. (мл.)AverbakhM. M. (Jr)

д.м.н., профессор, главный научный сотрудник отдела иммунологии.

PhD, MD (Medicine), Professor, Main Research Associate, Department of Immunology,.

amm50@mail.ruПановаЛ. В.PanovaL. V.

д.м.н., ведущий научный сотрудник детско-подросткового отдела.

PhD, MD (Medicine), Senior Research Associate, Pediatric Department.

ГубкинаМ. Ф.GubkinaM. F.

д.м.н., ведущий научный сотрудник детско-подросткового отдела.

PhD, MD (Medicine), Senior Research Associate, Pediatric Department.

ЕвсееваН. И.EvseevaN. I.

младший научный сотрудник детско-подросткового отдела.

Junior Research Associate, Pediatric Department.

ФГБНУ «Центральный научно-исследовательский институт туберкулеза».РоссияCentral Research Institute for Tuberculosis.Russian Federation201805112018205747752Copyright © Авербах М.М., Панова Л.В., Губкина М.Ф., Евсеева Н.И., 20182018Авербах М.М., Панова Л.В., Губкина М.Ф., Евсеева Н.И.Averbakh M.M., Panova L.V., Gubkina M.F., Evseeva N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1643

Цитолитические молекулы системы врожденного иммунитета гранулизин и кателицидин являются важными защитными факторами при инфицировании микобактериями туберкулеза. Нами получены данные о высоких показателях гранулизина и кателицидина у группы инфицированных МБТ детей и подростков. У больных туберкулезом органов дыхания показано низкое содержание сы вороточного кателицидина при деструктивных формах, а гранулизина – при «малых» формах тубер кулеза до начала специфической химиотерапии. Проведенная химиотерапия не оказывала влияния на содержание гранулизина и кателицидина в сыворотке у больных с деструктивным туберкулезом, тогда как у больных «малыми» формами (ТВГЛУ/очаговый туберкулез) выявлено достоверное увели чение содержания гранулизина через 6 месяцев лечения и кателицидина – через 3 месяца химиотера пии с последующим возвращением к исходному уровню.

Granulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group of children and adolescents with latent TB infection. Patients with tuberculosis of the respiratory system exhibit significantly lower amounts of serum cathelicidin in destructive forms, as well as granulysin levels in “minor” forms of tuberculosis before starting the specific chemotherapy. The chemotherapy performed did not influence the serum granulysin and cathelicidin contents in patients with destructive tuberculosis, whereas the patients with “minor” forms (TLN/focal tuberculosis) revealed a significant increase in granulysin content after 6 months of treatment, and same trend for cathelicidin concentrations after 3 months of chemotherapy, followed by subsequent return to baseline values.

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The authors declare that there are no conflicts of interest present.