mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2019-4-595-602mimmun-1620Research ArticleОБЗОРЫREVIEWSЗАВИСИМОЕ ОТ ЛЕКТИНОВ РАЗНООБРАЗИЕ ПОПУЛЯЦИЙ ПРИРОДНЫХ КИЛЛЕРНЫХ КЛЕТОК В КОММУНИКАЦИЯХ ПРОТИВ ОПУХОЛЕЙ И ВИРУСОВLECTIN-DEPENDENT DIVERSITY OF NATURAL KILLER POPULATIONS AND COMMUNICATIONS AGAINST TUMORS AND VIRUSESЛахтинМ. В.LakhtinM. V.

к.б.н., старший научный сотрудник

125212, Россия, Москва, ул. Адмирала Макарова, 10

+7 (495) 452-18-16

PhD (Medicine), Senior Research Associate

125212, Russian Federation, Moscow, Adm. Makarov str., 10

+7 (495) 452-18-16

info@gabrich.comЛахтинВ. М.LakhtinV. M.

д.б.н., главный научный сотрудник

PhD, MD (Medicine), Chief Research Associate, G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology,

Moscow

Lakhtinv@yandex.ruАлешкинВ. А.AleshkinV. A.

д.б.н., профессор, научный руководитель

PhD, MD Professor (Medicine), Research Director

Moscow

info@gabrich.comАфанасьевС. С.AfanasievS. S.

д.м.н., профессор, главный научный сотрудник 

PhD, MD (Medicine), Chief Research Associate – Doctor of Medical Sciences, Professor, Chief Research Officer

Moscow

afanasievss409.4@bk.ruФБУН «Московский научно-исследовательский институт эпидемиологии и микробиологии имени Г.Н. Габричевского» РоспотребнадзораРоссияG.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyRussian Federation201911032019214препринт595602Copyright © Лахтин М.В., Лахтин В.М., Алешкин В.А., Афанасьев С.С., 20192019Лахтин М.В., Лахтин В.М., Алешкин В.А., Афанасьев С.С.Lakhtin M.V., Lakhtin V.M., Aleshkin V.A., Afanasiev S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1620

Популяции природных киллерных клеток человека (ППККЧ) против опухолей в присутствии вирусов оценены как сильно варьирующие и рано адаптированные к патологическим сигналам в организме мобильные и избирательно действующие способные к комбинированию агенты. ППККЧ осуществляют различные действия в результате кофункционирования рецепторных лектинов (РЛ), распознающих гликопаттерны (РЛ как триггеры, инициаторы и базисные агенты для надстроечных реакций), и Ig-подобных, цитотоксических и прочих вспомогательных коммуникативных и эффекторных рецепторов (роль РЛ как инструментов тонкой настройки мозаики поверхностноклеточных рецепторов в направлении необходимой функциональной ориентации ППККЧ), а также их лигандов (модуляторов созданных конечных рецепторных мозаик). Такие наученные и переобученные ППККЧ играют важную роль в перераспределении ППККЧ-индуцированных паротиворопухолевых и антивирусных цитокиновых наборов в организме. Межклеточный коммуникативный потенциал ППККЧ также учитывает другие клетки врожденного иммунитета и адаптированные для врожденного иммунитета клетки, что может служить перспективным и универсальным ресурсом защиты человека. ППККЧ должны учитываться при разработке товых маневренных и надежных сбалансированных профилактических и иммунотерапевтических противоопухолевых/ антивирусных систем и вакцинных стратегий. Открыты пути к алгоритмам тонкой настройки (РЛ—KIR/ NCR/ CD/ их комбинации)  РЛ-базисного конструирования веера противоопухолевых/ антивирусных ППККЧ с дальнейшим потенциалом инициирования. Ключевую важность приобретает скрининг спектра ППККЧ у индивидуума и потенциального пациента для дополнительной оценки защитного статуса и выработки персонизированных коммуникативных противоопухолевых/ антивирусных стратегий. Установленный статус NK(natural killers)-компартмента будет характеризовать резистентность индивидуума/ контингента индивидуумов против вирусных инфекаций эпидемиологической значимости, играть важную роль при оценке противоэпидемической защиты региона.

 

Response of human natural killer (NK) cell populations (NKP) against tumors in the presence of viruses was evaluated as a quite variable, early adapting for the pathological signals in organism, mobile and selective combination agents. NKP act as a result of co-functioning between the receptor lectins (RL) recognizing glycopatterns (RL as triggers, initiators and basic agents for coupled activities), and Ig-like, cytotoxic and other additional  communicative and effector receptors (superstructural, tuning for achievement of final effector-type NKP constructions required), and their ligands (modulators of final cell surface receptor mosaics). Such NKP created play important role in redistribution of NKP-induced antitumor/ antiviral cytokines in organism. Intercellular communicative potential of NKP also involves other innate and innate-like cells. Such extended communications of NKP provide a prospective and universal resource of human protection. NKP must be under consideration upon development of new maneuvre and relilable prophylactic and immunotherapeutic antitumor/ antiviral systems and vaccine strategies. The ways for the fine tuning (RL—KIR/ NCR/ CD/ their combinations) algorithms of RL-based creation of antitumor/ antiviral NKP are revealed. Key role is given to screening spectrum of patient NKP for development of communicative anticancer/ antiviral strategies. The status of NK compartment will characterize resistance of individuum/ contingent of individuums to viral infections of epidemiological significance, will play important role in anti-epidemic protection of regional population.

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The authors declare that there are no conflicts of interest present.