mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2019-4-633-642mimmun-1607Research ArticleОБЗОРЫREVIEWSРОЛЬ ПЕРИВАСКУЛЯРНОЙ ЖИРОВОЙ ТКАНИ В РАЗВИТИИ АТЕРОСКЛЕРОТИЧЕСКИХ И НЕАТЕРОСКЛЕРОТИЧЕСКИХ ЗАБОЛЕВАНИЙROLE OF PERIVASCULAR ADIPOSE TISSUE IN THE DEVELOPMENT OF ATHEROSCLEROTIC AND NONATHEROSCLEROTIC DISEASESУчасоваЕ. Г.UchasovaE. G.

к.м.н., старший научный сотрудник лаборатории исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

650002, Россия, г. Кемерово, Сосновый бульвар, 6

Тел.: 8 (3842) 64-05-53

PhD (Medicine), Senior Research Associate, Laboratory of Homeostasis Research

650002, Russian Federation, Kemerovo, Sosnovy bvld, 6

Phone: 7 (3842) 64-05-53

evg.uchasova@yandex.ruГруздеваО. В.GruzdevaO V

д.м.н., заведующая лабораторией исследования гомеостаза отдела диагностики сердечно-сосудистых заболеваний; доцент кафедры патологической физиологии, медицинской и клинической биохимии

PhD, MD (Medicine), Head, Laboratory of Homeostasis Research; Associate Professor, Department of Pathological Physiology

650002, Russian Federation, Kemerovo, Sosnovy bvld, 6

xxx@mail.ruДылеваЮ. А.DylevaYu A

к.м.н., старший научный сотрудник лаборатории исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

PhD (Medicine), |Senior Research Associate, Laboratory of Homeostasis Research

650002, Russian Federation, Kemerovo, Sosnovy bvld, 6

xxx@mail.ruБеликЕ. В.BelikE V

младший научный сотрудник лаборатории исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

Junior Research Associate, Laboratory of Homeostasis Research

650002, Russian Federation, Kemerovo, Sosnovy bvld, 6

xxx@mail.ruФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Research Institute for Complex Issues of Cardiovascular DiseasesRussian FederationФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения РФRussian FederationFederal State Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityRussian Federation201911032019214препринт633642Copyright © Учасова Е.Г., Груздева О.В., Дылева Ю.А., Белик Е.В., 20192019Учасова Е.Г., Груздева О.В., Дылева Ю.А., Белик Е.В.Uchasova E.G., Gruzdeva O.V., Dyleva Y.A., Belik E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1607

Периваскулярная жировая ткань (ПВЖТ) окружает большинство крупных кровеносных сосудов и играет важную роль в сосудистом гомеостазе. Недавние исследования показали, что ПВЖТ влияет на вазодилатацию и вазоконстрикцию, что указывает на то, что ПВЖТ регулирует тонус и диаметр сосудов. Адипоцитокины и хемокины, секретируемые из ПВЖТ, по-видимому, имеют прямой доступ к соседней артериальной стенке путем диффузии или через vasa vasorum. Установленные данные свидетельствуют о том, что ПВЖТ играет важную роль в атеросклерозе, гипертонии, недавно появились исследования, в которых изучалась роль ПВЖТ в неатеросклеротических сосудистых заболеваниях, таких как неоинтимальные новообразование, аневризма аорты, артериальная ригидность и васкулит. В этой обзорной статье мы обобщим данные о роли ПВЖТ в патогенезе атеросклероза, гипертонии и неатеросклеротических сосудистых заболеваниях.

Perivascular adipose tissue surrounds most large blood vessels and plays an important role in vascular homeostasis. Recent studies have shown that perivascular adipose tissue effects vasodilation and vasoconstriction, which indicates that the perivascular adipose tissue regulates tone and diameter of the vessels. Adipocytokines and chemokines, secreted from the perivascular adipose tissue, apparently have direct access to the adjacent arterial wall by diffusion, or through vasa vasorum. The present data indicate that perivascular adipose tissue plays an important role in atherosclerosis, hypertension. Recently, some studies were performed that examined the role of perivascular adipose tissue in non-atherosclerotic vascular diseases, such as neointimal formation, aortic aneurysm, arterial stiffness and vasculitis. The present review will discuss a role of perivascular adipose tissue in pathogenesis of atherosclerosis, hypertension and non-atherosclerotic vascular diseases.

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The authors declare that there are no conflicts of interest present.