mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2018-4-463-476mimmun-1556Research ArticleОБЗОРЫREVIEWSПУРИНЕРГИЧЕСКАЯ РЕГУЛЯЦИЯ ОСНОВНЫХ ФИЗИОЛОГИЧЕСКИХ И ПАТОЛОГИЧЕСКИХ ПРОЦЕССОВPURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSESГоловкинА. С.GolovkinA. S.

д.м.н., руководитель группы, Институт молекулярной биологии и генетики,

197341, Санкт-Петербург, ул. Аккуратова, 2

PhD, MD (Medicine), Head of a Research Group, Institute of Molecular Biology and Genetics,

197341, St. Petersburg, Akkuratova str., 2

golovkin_a@mail.ruАсадуллинаИ. А.AsadullinaI. A.

младший научный сотрудник отдела иммунологии,

Санкт-Петербург

Junior Research Associate, Department of Immunology,

St. Petersburg

КудрявцевИ. В.KudryavtsevI. V.

к.б.н., старший научный сотрудник отдела иммунологии;

доцент кафедры иммунологии,

Санкт-Петербург

PhD (Biology), Senior Research Associate, Department of Immunology;

Assistant Professor, Department of Immunology, 

St. Petersburg

ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова»РоссияV.A. Almazov National Medical Research CentreRussian FederationФГБНУ «Институт экспериментальной медицины»РоссияInstitute of Experimental MedicineRussian FederationФГБНУ «Институт экспериментальной медицины»; ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения РФРоссияInstitute of Experimental Medicine; First St. Petersburg State I.P. Pavlov Medical UniversityRussian Federation201824062018204463476Copyright © Головкин А.С., Асадуллина И.А., Кудрявцев И.В., 20182018Головкин А.С., Асадуллина И.А., Кудрявцев И.В.Golovkin A.S., Asadullina I.A., Kudryavtsev I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1556

В последние годы ведется активное изучение значимости пуринергического сигналинга в патогенезе широкого спектра заболеваний и патологических состояний, к числу которых относятся регуляция инфекционного и неинфекционного воспаления, опухолевого роста и метастазирования, реакций отторжения трансплантата, аутоиммунных заболеваний, кальцификации элементов сердечно-сосудистой системы и т.д. Было показано, что пуринергическая система осуществляет тонкую регуляцию функций клеток иммунной системы аналогично цитокиновой и хемокиновой секреции, удалению внутриклеточных патогенов и механизмов клеточной гибели. Основываясь на понимании механизмов развития этих состояний, в том числе и участии пуринергической системы в их регуляции, разрабатываются новые подходы к терапии и профилактике. Анализу достижений последнего времени в участии пуринергической регуляции в основных патологических состояниях и заболеваниях, а также трендам в разработке терапевтических подходов на основании полученных знаний посвящен данный обзор.

Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease, autoimmune disorders, cardiovascular calcification etc. It has been shown that the purinergic system mediates fine tuning of the immune cell populations, like as cytokine and chemokine secretion, elimination of intracellular pathogens and mechanisms of programmed cell death. Novel approaches to therapy and disease prevention are based on studies of appropriate developmental mechanisms, including role of purinergic system in their regulation. This review contains analysis of recent achievements elucidating the role of purinergic regulation in pathogenesis of basic pathological conditions and diseases, as well as trends in development of new therapeutic approaches based on present knowledge.

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The authors declare that there are no conflicts of interest present.