mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2010-4-5-337-342mimmun-150Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЭКСПРЕССИЯ АДГЕЗИОННЫХ МОЛЕКУЛ МОНОЦИТАМИ ПЕРИФЕРИЧЕСКОЙ КРОВИ ПРИ БЕРЕМЕННОСТИEXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCYМихайловаВ. А.MikhaylovaV. A.kva.spb@mail.ruКлимовскаяЯ. С.KlimovskayaY. S.kva.spb@mail.ruАмановаН. В.AmanovaN. V.kva.spb@mail.ruЗайнулинаМ. С.ZaynulinaM. S.kva.spb@mail.ruСельковС. А.SelkovS. A.kva.spb@mail.ruСоколовД. И.SokolovD. I.kva.spb@mail.ruУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургRussian Federation201016072014124-5337342Copyright © Михайлова В.А., Климовская Я.С., Аманова Н.В., Зайнулина М.С., Сельков С.А., Соколов Д.И., 20142014Михайлова В.А., Климовская Я.С., Аманова Н.В., Зайнулина М.С., Сельков С.А., Соколов Д.И.Mikhaylova V.A., Klimovskaya Y.S., Amanova N.V., Zaynulina M.S., Selkov S.A., Sokolov D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/150

Peripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expression of CD11a, CD11b, CD11c, CD18, CD49d, CD29 markers of monocytes from non-pregnant and pregnant women. Expression of adhesion molecules on monocytes was analyzed by flow cytometry. The amounts of CD11b-expressing monocytes increased during pregnancy, as compared with non-pregnant women. Intensity of CD11a, CD11b, CD11c, CD29 expression on the monocytes did also increase at normal pregnancy. These results suggest that intense adhesion of monocytes to endothelium during uncomplicated pregnancy may be determined by increased expression of CD11a, CD11b, CD11c, CD29, and higher amounts of CD11b+ monocytes.

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The authors declare that there are no conflicts of interest present.