mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2017-4-329-358mimmun-1307Research ArticleОБЗОРЫREVIEWSРАЗРАБОТКА ВАКЦИН НА ОСНОВЕ АДЕНОВИРУСНЫХ ВЕКТОРОВ: ОБЗОР ЗАРУБЕЖНЫХ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙ (ЧАСТЬ 2)DEVELOPMENT OF VACCINES BASED ON ADENOVIRAL VECTORS: A REVIEW OF FOREIGN CLINICAL STUDIES (PART 2)ЧереноваЛ. В.CherenovaL. V.

Черенова Любовь Викторовна – кандидат биологических наук,  научный сотрудник лаборатории молекулярной  биотехнологии.

123098, Москва, ул. Гамалеи, 18, тел.: 8 (916) 329-92-78, факс: 8 (499) 193-61-35

Cherenova Liubov V. - PhD (Biology), Research Associate, Laboratory of Molecular Biotechnology.

123098, Moscow, Gamaleya str., 18. Phone: 7 (916) 329-92-78. Fax: 7 (499) 193-61-35

cherenova@yandex.ruКаштигоТ. В.KashtigoT. V.

Кандидат биологических наук,  научный сотрудник лаборатории клеточной микробиологии.

Москва

PhD (Biology), Research Associate, Laboratory of Cellular Microbiology.

Moscow

СаядянХ. С.SaiadianKh. S.

PhD, MD (Medicine), Professor, Department of Pharmaceutical Technology and Pharmacology.

Moscow

ШмаровМ. М.ShmarovM. M.

Доктор биологических наук, заведующий  лабораторией молекулярной  биотехнологии.

Москва

PhD, MD (Biology), Head, Laboratory of Molecular Biotechnology.

Moscow

ФГБУ «Федеральный научно-исследовательский центр эпидемиологии и микробиологии им. почетного академика Н.Ф. Гамалеи» Министерства здравоохранения РФРоссияN. Gamaleya Research Institute of Epidemiology and MicrobiologyRussian FederationГБОУ ВПУ «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФРоссияFirst Moscow I. Sechenov State Medical UniversityRussian Federation201730082017194329358Copyright © Черенова Л.В., Каштиго Т.В., Саядян Х.С., Шмаров М.М., 20172017Черенова Л.В., Каштиго Т.В., Саядян Х.С., Шмаров М.М.Cherenova L.V., Kashtigo T.V., Saiadian K.S., Shmarov M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1307

В настоящее время для  многих инфекционных  заболеваний человека не  разработаны эффективные способы лечения и профилактики. Одним из  последних достижений биотехнологии является использование аденовирусных векторов, несущих иммунодоминантные антигены различных патогенов, в качестве генно-инженерных вакцин как профилактических, так и терапевтических. Использование генно-инженерных  технологий позволяет не  применять при  производстве вакцин живые вирусы и бактерии, сокращает время разработки и получения новых  вакцинных препаратов. Аденовирусные векторы естественным путем проникают в клетки человека, вызывая довольно длительный и значительный как  гуморальный, так и клеточный иммунный ответ.  Во второй части  обзора  мы  планируем привести сведения о проводимых в настоящее время за рубежом клинических испытаниях вакцин на  основе аденовирусных векторов против таких  инфекционных заболеваний, как грипп, малярия, геморрагическая лихорадка Эбола, туберкулез, гепатит и ряда других. Будут рассмотрены параметры отбора  добровольцев, схемы и дозы, используемые при вакцинации, приведены результаты завершенных экспериментов  и предварительные результаты незаконченных на  данный момент исследований.

Currently, many human infectious diseases do not developed effective methods of treatment and prevention. One of the latest successes of biotechnology is the use of adenoviral vectors carrying immunodominant antigens  of various pathogens as genetically engineered vaccines  both  preventive and therapeutic. The use of genetic  engineering technologies allows not  to use in the  manufacture of vaccines  live viruses and  bacteria, reduces  the  time  needed for vaccine  creation and  production of new vaccines.  Adenoviral vectors  naturally penetrate into human cells, causing a rather  long and significant  both humoral and cellular immune response. In the second  part of review, we provide  information about  the ongoing  worldwide  clinical  trials of adenoviral vector-based vaccines against various infectious diseases such as influenza, malaria, Ebola haemorrhagic fever, tuberculosis, hepatitis and  several others, like as to consider selection parameters of volunteers, vaccination schedule, doses of drug administration, results of completed experiments, and preliminary data  on currently ongoing  research.

аденовирусный векторвакцинаклинические испытанияинфекционные заболеванияаденовирус человекааденовирус шимпанзеadenoviral vectorvaccineclinical trialsinfectious diseaseshuman adenoviruschimpanzee adenovirusReferencesЧеренова Л.В., Каштиго Т.В., Саядян Х.С., Шмаров М.М. Разработка вакцин на основе аденовирусных векторов: обзор зарубежных клинических исследований (Часть1) // Медицинская иммунология, 2017. Т. 19, № 2. С. 111-126. [Cherenova L.V., Kashtigo T.V., Saiadian K.S., Shmarov M.M. Development of vaccines based on adenoviral vectors: a review of foreign clinical studies (Part 1). Meditsinskaya immunologiya = Medical Immunology (Russia), 2017, Vol. 19, no. 2, pp. 111-126. (In Russ.)] doi: 10.15789/1563-0625-2017-2-111-126.Черенова Л.В., Каштиго Т.В., Саядян Х.С., Шмаров М.М. Разработка вакцин на основе аденовирусных векторов: обзор зарубежных клинических исследований (Часть1) // Медицинская иммунология, 2017. Т. 19, № 2. С. 111-126. 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The authors declare that there are no conflicts of interest present.