mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2017-3-313-318mimmun-1266Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSОСОБЕННОСТИ ЦИТОКИНОВОГО СПЕКТРА У БОЛЬНЫХ НЕАЛЛЕРГИЧЕСКОЙ БРОНХИАЛЬНОЙ АСТМОЙ В СОЧЕТАНИИ С СОПУТСТВУЮЩИМ САХАРНЫМ ДИАБЕТОМ 2 ТИПАCYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUSСорокинаЛ. Н.SorokinaL. N.

д.м.н., профессор, кафедра госпитальной терапии с курсом аллергологии и иммунологии им. акад. М.В. Черноруцкого

PhD, MD (Medicine), Professor, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology

minvn@spmu.rssi.ruИвановВ. А.IvanovV. A.

очный аспирант, кафедра госпитальной терапии с курсом аллергологии и иммунологии им. акад. М.В. Черноруцкого

Research Fellow, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology

minvn@spmu.rssi.ruМинеевВ. Н.LimV. V.

д.м.н., профессор, кафедра госпитальной терапии с курсом аллергологии и иммунологии им. акад. М.В. Черноруцкого

PhD (Medicine), Senior Laboratory Assistant, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology

minvn@spmu.rssi.ruЛимВ. В.MineevV. N.

к.м.н., старший лаборант, кафедра госпитальной терапии с курсом аллергологии и иммунологии им. акад. М.В. Черноруцкого

PhD, MD (Medicine), Professor, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology

minvn@spmu.rssi.ruТрофимовВ. И.TrofimovV. I.

д.м.н., профессор, заведующий кафедрой, кафедра госпитальной терапии с курсом аллергологии и иммунологии им. акад. М.В. Черноруцкого

PhD, MD (Medicine), Professor, Head, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology

minvn@spmu.rssi.ruГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Министерства здравоохранения РФ, Санкт-ПетербургРоссияFirst St. Petersburg I. Pavlov State Medical University, St. PetersburgRussian Federation201704072017193313318Copyright © Сорокина Л.Н., Иванов В.А., Минеев В.Н., Лим В.В., Трофимов В.И., 20172017Сорокина Л.Н., Иванов В.А., Минеев В.Н., Лим В.В., Трофимов В.И.Sorokina L.N., Ivanov V.A., Lim V.V., Mineev V.N., Trofimov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1266

Нами обследовано: 31 практически здоровый человек и 35 больных неаллергической БА (НАБА), 22 больных НАБА в сочетании с сахарным диабетом 2 типа (СД2), 23 больных СД2. Определение концентрации IL-4, IL-10, IL-6, IFNγ проводилось методом ИФА по стандартным протоколам с помощью коммерческих наборов («Вектор-Бест» и «Цитокин», Россия). В обследованной популяции больных с сочетанием БА и СД2T бронхиальная астма была представлена неаллергическим вариантом, что, по-видимому, согласуется с высказанным ранее предположением об особенностях инсулин-рецепторных взаимодействий при бронхиальной астме. В группе больных с сочетанием БА и СД2T было выявлено значимое нарастание уровней IL-6, IFNγ и снижение IL-4 по сравнению с контролем и НАБА; также выявлено нарастание уровней IL-4, IL-6, IFNγ по сравнению с СД2. Выявленные нами клинико-патогенетические особенности у больных БА в сочетании с СД2 могут указывать на существование дисбаланса про- и противовоспалительных цитокинов у этих больных, который может приводить к прогрессированию нарушения углеводного обмена, с повышением гликирования и нарастанием изменений в бронхолегочной системе. 

Thirty-five patients with non-allergic bronchial asthma (NABA), 22 patients with NABA and diabetes mellitus type 2 (DT2), 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immunoassay kits purchased from VectorBest, and Cytokine. In asthma patients complicated by DT2, the pattern of bronchial asthma was ascribed to NABA. This finding may be consistent with a theory of specific insulin-receptor interactions in asthma. The NABA patients with type 2 diabetes mellitus exhibited a significant increase in IL-6, IFNγ, and decrease of IL-4, as compared with healthy controls and NABA. Moreover, we have revealed an increase of IL-4, IL-6, IFNγ, when compared with DT2. Hence, the patients with coexistence of non-allergic bronchial asthma and DT2 were characterized by a specific cytokine profile of pro- and anti-inflammatory cytokines, which may correlate with increased glycation and deterioration of lung function.

 

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The authors declare that there are no conflicts of interest present.