mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2017-2-145-156mimmun-1227Research ArticleОБЗОРЫREVIEWSПРОТИВОРАКОВАЯ ДНК-ВАКЦИНАЦИЯ: ПРИНЦИП И ВОЗМОЖНОСТИ МЕТОДАANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHODСтёганцеваМ. В.StegantsevaM. V.

магистр биологических наук, младший научный сотрудник лаборатории генетических биотехнологий

MBs, Junior Research Associate, Laboratory of Molecular Genetic Research

stsegantsevam@gmail.comМелешкоА. Н.MeleshkoA. N.

к.б.н., заведующий лабораторией молекулярно-генетических исследований

PhD (Biology), Head, Laboratory of Molecular Genetic Research

stsegantsevam@gmail.comРеспубликанский научно-практический центр детской онкологии, гематологии и иммунологииБеларусьBelarussian Research Center for Pediatric Oncology, Hematology and ImmunologyBelarus201706052017192145156Copyright © Стёганцева М.В., Мелешко А.Н., 20172017Стёганцева М.В., Мелешко А.Н.Stegantseva M.V., Meleshko A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1227Резюме

Резюме. Традиционные методы лечения онкологических заболеваний приближаются к пределу своей эффективности. Стремительное развитие иммунологии и экспериментальной иммунотерапии привело к первым успехам вакцинации против опухолей. Последняя декада знаменательна переходом вакцинации из лаборатории в онкологическую клинику и ростом популярности ДНК-вакцин. На сегодняшний день накоплен большой массив экспериментальных данных и результатов клинических испытаний, связанных с разнообразными способами получения и применения ДНК-вакцин. В данном обзоре рассмотрены принципы получения ДНК-вакцин, разнообразие их конструкций, механизм действия, формы и способы доставки в организм.

 

 

Conventional strategies for cancer treatment are close to their efficiency limits. Meanwhile, rapid development of experimental immunology and immunotherapy led to first successful experiences in antitumor vaccination. Over last decade, remarkable results were obtained by means of anticancer vaccination being implemented into clinical settings thus causing popularity and growth of interest to tumor-specific DNA vaccines. In this review, we discuss basic principles of a DNA vaccine construction, their structural characteristics and diversity, mechanisms of their biological action, pharmaceutical forms and delivery routes into the body.

 

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The authors declare that there are no conflicts of interest present.