mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2017-2-127-144mimmun-1217Research ArticleОБЗОРЫREVIEWSКРАТКИЙ ОБЗОР КЛИНИЧЕСКИХ ИСПЫТАНИЙ СРЕДСТВ ИММУНОТЕРАПИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙSHORT OVERVIEW OF CLINICAL TRIALS WITH CURRENT IMMUNOTHERAPEUTIC TOOLS FOR CANCER TREATMENTНепомнящихТ. С.NepomnyashchikhT. S.

к.б.н., старший научный сотрудник

PhD (Biology), Senior Research Associate

antonec@ngs.ruАнтонецД. В.AntonetsD. V.

к.б.н., старший научный сотрудник

PhD (Biology), Senior Research Associate

antonec@ngs.ruМаксютовР. А.MaksyutovR. A.

к.б.н., врио генерального директора

PhD (Biology), Acting General Director

antonec@ngs.ruФБУН «Государственный научный центр вирусологии и биотехнологии “Вектор”» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияState Research Center of Virology and Biotechnology “Vector”, Federal Service for Surveillance on Consumer Rights Protection and Human WelfareRussian Federation201705052017192127144Copyright © Непомнящих Т.С., Антонец Д.В., Максютов Р.А., 20172017Непомнящих Т.С., Антонец Д.В., Максютов Р.А.Nepomnyashchikh T.S., Antonets D.V., Maksyutov R.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1217

В течение последнего десятилетия был достигнут большой прогресс в понимании биологии рака и его взаимодействия с иммунной системой. В клинической практике для лечения онкологических заболеваний широко применяются иммунотерапевтические препараты на основе рекомбинантных цитокинов и моноклональных антител, разработано большое количество экспериментальных способов лечения онкологических заболеваний, многие из которых в данный момент проходят различные стадии клинических испытаний. Одобрение рекомбинантного онколитического герпесвируса T-VEC для лечения меланомы стало очередным важным шагом на пути к созданию эффективных и безопасных противораковых препаратов. В данном обзоре мы рассмотрим некоторые наиболее перспективные стратегии иммунотерапии онкологических заболеваний: ингибиторы контрольных точек иммунного ответа, клеточную терапию и онколитические вирусы.

 

Over last decade, a substantial progress has been made, with respect to understanding of cancer biology and its interplay with the host immune system. Different immunotherapeutic drugs based on recombinant cytokines and monoclonal antibodies are widely used in cancer therapy, and a large number of experimental cancer treatments have been developed, many of which are currently undergoing various stages of clinical trials. Recent endorsement of a recombinant oncolytic herpesvirus T-VEC for the treatment of melanoma was an important step towards a more safe and efficient anticancer therapeutics. In this review, we shall mention only some of the most promising cancer immunotherapy strategies, namely, immune checkpoint inhibitors, cellular therapy and oncolytic viruses.

 

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[Moiseenko V.M., Volkov N.M. The most important events in the oncology in 2014: cancer immunotherapy. Prakticheskaya onkologiya = Practical Oncology, 2015, Vol. 16, no. 1, pp. 6-12. (In Russ.)]Нетёсов С.В., Кочнева Г.В., Локтев В.Б., Святченко В.А., Сергеев А.Н., Терновой В.А., Тикунова Н.В., Шишкина Л.Н., Чумаков П.М. Онколитические вирусы: достижения и проблемы // Медицинский алфавит, 2011. № 3. С. 26-33. [Netesov S.V., Kochneva G.V., Loktev V.B., Sviatchenko V.A., Sergeev A.N., Ternovoi V.A. Tikunova N.V., Shishkina L.N., Chumakov P.M. Oncolytic viruses: achievements and problems. Meditsinskiy alfavit = Medical Alphabet, 2011, no. 3, pp. 26-33. (In Russ.)]Нетёсов С.В., Кочнева Г.В., Локтев В.Б., Святченко В.А., Сергеев А.Н., Терновой В.А., Тикунова Н.В., Шишкина Л.Н., Чумаков П.М. Онколитические вирусы: достижения и проблемы // Медицинский алфавит, 2011. № 3. С. 26-33. [Netesov S.V., Kochneva G.V., Loktev V.B., Sviatchenko V.A., Sergeev A.N., Ternovoi V.A. 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The authors declare that there are no conflicts of interest present.