mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2016-6-521-536mimmun-1132Research ArticleОБЗОРЫREVIEWSРОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4+Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИTHE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4+Т LYMPHOCYTES DURING PREGNANCYСоколовД. И.SokolovD. I.

 д.б.н., заведующий лабораторией межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий 

PhD, MD (Biology), Head, Cell Interactions Laboratory, Department of Immunology and Cell Interactions

falcojugger@yandex.ruСтепановаО. И.StepanovaO. I.

к.б.н., старший научный сотрудник лаборатории межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий 

PhD (Biology), Senior Research Associate, Cell Interactions Laboratory, Department of Immunology and Cell Interactions

falcojugger@yandex.ruСельковС. А.SelkovS. I.

 д.м.н., профессор, руководитель отдела иммунологии и межклеточных взаимодействий 

PhD, MD (Medicine), Professor, Head, Department of Immunology and Cell Interactions

falcojugger@yandex.ruФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им Д.О. Отта» Санкт-Петербург, РоссияРоссияD.O. Ott Research Institute of Obstetrics, Ginecology and Reproductology, St. Petersburg, Russian FederationRussian Federation201607122016186521536Copyright © Соколов Д.И., Степанова О.И., Сельков С.А., 20162016Соколов Д.И., Степанова О.И., Сельков С.А.Sokolov D.I., Stepanova O.I., Selkov S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1132

Важную роль в формировании иммунологической толерантности при беременности играют Т-лимфоциты. В настоящем обзоре рассматривается характеристика Т-лимфоцитов децидуальной оболочки и плаценты, особенности их миграции и функциональной активности при беременности. В обзоре обсуждается роль субпопуляций Th1-, Th17-, Th2- и Treg-лимфоцитов в формировании плаценты и иммунорегуляции беременности, а также их взаимодействие с клетками децидуальной оболочки и трофобласта.

An important role in the formation of immunological tolerance during pregnancy play T lymphocytes. In the present review discusses the characteristics of T lymphocytes, decidua and placenta, especially their migration and functional activity during pregnancy. The review discusses the role of the subpopulations of Th1, Th17, Th2 and Treg lymphocytes in the formation of the placenta and the immune regulation of pregnancy, as well as their interaction with the cells of the decidua and trophoblast.

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The authors declare that there are no conflicts of interest present.