mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-2-155-162mimmun-106Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВЛИЯНИЕ СЕКРЕТОРНЫХ ПРОДУКТОВ ТКАНИ ПЛАЦЕНТЫ НА ФЕНОТИП И АКТИВНОСТЬ ТРАНСЭНДОТЕЛИАЛЬНОЙ МИГРАЦИИ МОНОЦИТОПОДОБНЫХ КЛЕТОК ЛИНИИ THP-1FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCEКологривоваИ. В.KologrivovaI. V.

научный сотрудник

Research Associate

ikologrivova@gmail.comСусловаТ. Е.SuslovaT. E.

к.м.н., ведущий научный сотрудник

PhD (Medicine), Leading Researcher

ikologrivova@gmail.comКошельскаяО. А.KoshelskayaO. A.

д.м.н., профессор, ведущий научный

PhD, MD (Medicine), Professor, Leading Researcher

ikologrivova@gmail.comВинницкаяИ. В.VinnizkayaI. V.

научный сотрудник

Research Associate

ikologrivova@gmail.comТрубачеваО. А.TrubachevaO. A.

к.м.н., научный сотрудник

PhD (Medicine), Research Associate

ikologrivova@gmail.comЖелтоноговаН. М.ZheltonogovaN. M.

главный специалист

Chief specialist

ikologrivova@gmail.comГусаковаА. М.GusakovaA. M.

к.ф.н., научный сотрудник

Research Associate

ikologrivova@gmail.comФедеральное государственное бюджетное учреждение «Научно-исследовательский институт кардиологии» Сибирского отделения Российской академии медицинских наук, г. ТомскРоссияResearch Institute of Cardiology, Russian Academy of Medical Sciences, Siberian Branch, TomskRussian Federation201315072014152155162Copyright © Кологривова И.В., Суслова Т.Е., Кошельская О.А., Винницкая И.В., Трубачева О.А., Желтоногова Н.М., Гусакова А.М., 20142014Кологривова И.В., Суслова Т.Е., Кошельская О.А., Винницкая И.В., Трубачева О.А., Желтоногова Н.М., Гусакова А.М.Kologrivova I.V., Suslova T.E., Koshelskaya O.A., Vinnizkaya I.V., Trubacheva O.A., Zheltonogova N.M., Gusakova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/106

Показано, что для пациентов с  артериальной гипертензией, ассоциированной с  сахар-ным диабетом 2-го типа, характерно снижение содержания FoxP3+Т-регуляторных клеток и повышение уровня антител к ткани сердца и ядерным антигенам. При сочетании нарушения толерантности к  углеводам и  артериальной гипертензии низкому количеству Т-регуляторных лимфоцитов сопутствовало повышенное содержание ревматоидного фактора и антимитохондриальных антител. Артериальная гипертензия ассоциировалась с дислипидемией и сопровождалась увеличением концентрации ревматоидного фактора и антител к ядерным антигенам. Во всех группах пациентов выявлены тесные корреляционные связи между содержанием аутоантител, количеством FoxP3+Т-регуляторных лимфоцитов и  параметрами углеводного и  липидного обмена. Полученные результаты свидетельствуют об ассоциации метаболических расстройств с нарушениями механизмов аутотолерантности в гуморальном звене иммунной системы, что проявляется уже на ранних этапах формирования сахарного диабета 2-го типа и может вносить вклад в развитие осложнений при данном заболевании.

When studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens. In a group with combination of impaired glucose tolerance and arterial hypertension, a decrease in T-regulatory lymphocytes’ numbers, along with increased rheumatoid factor and antimitochondrial autoantibodies concentrations were observed. Arterial hypertension was combined with dyslipidemia, being accompanied by higher levels of rheumatoid factor and antibodies to nuclear antigens. In all these clinical groups, we revealed close correlations between concentrations of autoantibodies, FoxP3+T-regulatory lymphocyte scores, and parameters of carbohydrate and lipid metabolism. The results, obtained in present study, allow us to suggest that metabolic disturbances may be associated with altered immune tolerance mechanisms and activation of humoral immune response that are detectable since early stages of the disease and may contribute to development of complications occurring in diabetes mellitus type 2.

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The authors declare that there are no conflicts of interest present.