mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2016-4-309-316mimmun-1053Research ArticleЛЕКЦИИLECTUREАДАПТИВНЫЙ Т-КЛЕТОЧНЫЙ ОТВЕТ В ПАТОГЕНЕЗЕ ВИРУСНОЙ ИНФЕКЦИИ, ОБУСЛОВЛЕННОЙ ВИРУСОМ ГЕПАТИТА СADAPTIVE T-CELL RESPONSE IN PATHOGENESIS OF HEPATITIS C INFECTIONОлейникЕ. А.OleynikE. A.

аспирант лаборатории клеточной иммунотерапии,

630099, г. Новосибирск, Ядринцевская ул., 14,

ct_lab@mail.ru

Postgraduate Student, Laboratory of Cellular Immunotherapy,

630099, Novosibirsk, Yadrintsevskaya str., 14,

ct_lab@mail.ru

oleynik-90@bk.ruЛеплинаО. Ю.LeplinaO. Yu.

д.м.н., ведущий научный сотрудник лаборатории клеточной иммунотерапии

PhD, MD (Medicine), Leading Research Associate, Laboratory of Cellular Immunotherapy

ОстанинА. А.OstaninA. A.

д.м.н., профессор, главный научный сотрудник лаборатории клеточной иммунотерапии

PhD, MD (Medicine), Professor, Main Research Associate, Laboratory of Cellular Immunotherapy

СтаростинаН. М.StarostinaN. M.

заслуженный врач РФ, к.м.н., заведующая отделением иммунологии Клиники иммунопатологии

Honored Doctor of Russian Federation, PhD (Medicine), Head, Immunology Department, Clinics of Immunopathology

ЧерныхЕ. Р.ChernykhE. R.

д.м.н., профессор, член-корр. РАН, заведующая лабораторией клеточной иммунотерапии

PhD, MD (Medicine), Professor, Corresponding Member, Russian Academy of Sciences, Head Laboratory of Cellular Immunotherapy

ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»РоссияResearch Institute of Fundamental and Clinical ImmunologyRussian Federation201622082016184309316Copyright © Олейник Е.А., Леплина О.Ю., Останин А.А., Старостина Н.М., Черных Е.Р., 20162016Олейник Е.А., Леплина О.Ю., Останин А.А., Старостина Н.М., Черных Е.Р.Oleynik E.A., Leplina O.Y., Ostanin A.A., Starostina N.M., Chernykh E.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1053

Вирусный гепатит С, будучи наиболее частой причиной поражения печени, представляет глобальную проблему, поскольку характеризуется широкой распространенностью, высокими показателями хронизации и значительно повышает риск возникновения цирроза печени и гепатоцеллюлярной карциномы. Многочисленными исследованиями показано, что ключевую роль в патогенезе и исходе инфекции, обусловленной вирусом гепатита С, играют антиген-специфические CD4+ и CD8+T-клетки. Развитие сильного устойчивого и мультиэпитопного Т-клеточного ответа приводит к элиминации вируса, тогда как несостоятельность адаптивного Т-клеточного ответа ассоциируется с персистенцией вируса. В настоящем обзоре приводятся данные о патогенетической значимости Т-клеточного ответа в элиминации вируса, вирусной персистенции и развитии гепатита, а также обсуждаются возможные механизмы несостоятельности Т-клеточного ответа при хронической инфекции.

Chronic viral hepatitis C is the most common cause of liver damage and the global problem worldwide since is characterized by a high prevalence, high chronization rates, and significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. Many studies have shown that antigen-specific СD4+ and CD8+T-cells play a key role in pathogenesis and outcome of the infection. While the strong sustained antigenspecific multi-epitopic T-cell response predicts successful viral elimination, a deficiency of adaptive immune response is associated with virus persistence. This review presents data about pathogenetic significance of T-cell response in viral elimination, viral persistence and hepatitis development. Possible mechanisms of T-cell response failure in chronic infection are discussed as well.

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The authors declare that there are no conflicts of interest present.