mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2016-3-279-286mimmun-1041Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESДИНАМИЧЕСКИЕ ИЗМЕНЕНИЯ ХЕМОКИНА CXCL-10 (IP-10) У ДЕТЕЙ И ПОДРОСТКОВ, БОЛЬНЫХ РАЗЛИЧНЫМИ ФОРМАМИ ТУБЕРКУЛЕЗА ОРГАНОВ ДЫХАНИЯDYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSISАвербах (мл.)М. М.Averbakh (Jr)M. M.

107564, Россия, Москва, Яузская аллея, 2. Тел.: 8 (499) 785-90-72. Факс: 8 (499) 785-91-08 д.м.н., профессор, главный научный сотрудник, отдел иммунологии

107564, Russian Federation, Moscow, Yausa Allee, 2. Phone: 7 (499) 785-90-72. Fax: 7 (499) 785-91-08 PhD, MD (Medicine), Professor, Main Research Associate, Department of Immunology

amm50@mail.ruПановаЛ. В.PanovaL. V.

д.м.н., ведущий научный сотрудник, детско-подростковый отдел

PhD, MD (Medicine), Professor, Leading Research Associate, Pediatric Department

ГубкинаМ. Ф.GubkinaM. F.

д.м.н., ведущий научный сотрудник, детско-подростковый отдел

PhD, MD (Medicine), Professor, Leading Research Associate

ФГБНУ «Центральный научно-исследовательский институт туберкулеза», Москва, РоссияРоссияCentral Research Institute for Tuberculosis, Moscow, Russian FederationRussian Federation201613072016183279286Copyright © Авербах (мл.) М.М., Панова Л.В., Губкина М.Ф., 20162016Авербах (мл.) М.М., Панова Л.В., Губкина М.Ф.Averbakh (Jr) M.M., Panova L.V., Gubkina M.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/1041

Хемокин CXCL-10 (IP-10) является одним из дополнительных гуморальных маркеров, применяемых наряду с определением антиген-индуцированного IFNγ для диагностики латентной туберкулезной инфекции человека. Динамика изменения IP-10 и его прогностическое значение в процессе лечения различных форм туберкулеза, особенно детско-подросткового возраста, является малоизученной проблемой. В настоящем исследовании выявлено увеличение спонтанной и антиген-индуцируемой продукции IP-10 у детей и подростков, больных туберкулезом, по сравнению с латентным формой туберкулеза с последующим ее значительным снижением в случаях успешной противотуберкулезной химиотерапии. При деструктивных формах туберкулеза, имеющих торпидное и прогрессирующее течение, подобная динамика отсутствовала.

CXCL10 (IP-10) chemokine is one of additional humoral markers applied along with determination of antigen-induced IFNγ for diagnosis of latent tuberculosis infection in humans. Dynamics of the IP-10 changes and its prognostic value in planning treatment for various forms of tuberculosis is a scarcely studied problem, especially, in children and adolescents. Present study has revealed an increase in spontaneous and antigen-induced IP-10 production in children and adolescents with overt tuberculosis, when compared with latent course of tuberculosis, followed by its significant reduction in cases of successful chemotherapy of tuberculosis. Such dynamics was not evident in destructive forms of tuberculosis manifesting as torpid and progressive infection.

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The authors declare that there are no conflicts of interest present.