References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2016-3-209-220

mimmun-1033

Research Article

ОБЗОРЫ

REVIEWS

НОВЫЕ УЧАСТНИКИ НАРУШЕНИЯ ТОЛЕРАНТНОСТИ К АНТИГЕНАМ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: К КОНЦЕПЦИИ ИММУНОПАТОГЕНЕЗА АУТОИММУННЫХ ЗАБОЛЕВАНИЙ ЩИТОВИДНОЙ ЖЕЛЕЗЫ (ОБЗОР ЛИТЕРАТУРЫ)

NEW PLAYERS IN ALTERED TOLERANCE TO THYROID GLAND ANTIGENS: AN IMMUNOPATHOGENESIS CONCEPT OF AUTOIMMUNE THYROID DISEASE (REVIEW)

Здор

В. В.

Zdor

V. V.

к.м.н., научный сотрудник центральной научно-исследовательской лаборатории 690002, Россия, г. Владивосток, пр. Острякова, 4. Тел.: 8 (914) 791-96-25

PhD (Medicine), Research Associate, Central Research Laboratory 690002, Russian Federation, Vladivostok, Ostryakov Ave, 4. Phone: 7 (914) 791-96-25

victoria.zdor@mail.ru

Маркелова

Е. В.

Markelova

E. V.

д.м.н., профессор, заведующая кафедрой нормальной и патологической физиологии

PhD, MD (Medicine), Head, Department of Normal and Pathological Human Physiology

Гельцер

Б. И.

Geltser

B. I.

д.м.н., профессор, член-корр. РАН, директор департамента фундаментальной и клинической медицины школы биомедицины Дальневосточного федерального университета и советник ректора по науке и инновациям

PhD, MD (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences, Director, Department of Fundamental and Clinical Medicine School of Biomedical Far Eastern Federal University

ГБОУ ВПО «Тихоокеанский государственный медицинский университет», г. Владивосток, РоссияРоссияPacific Ocean State Medical University, Vladivostok, Russian FederationRussian Federation

2016

11072016

183209220

2016

Здор В.В., Маркелова Е.В., Гельцер Б.И.

Zdor V.V., Markelova E.V., Geltser B.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/1033

Механизмы потери толерантности к аутоантигенам щитовидной железы до сих пор точно неизвестны, что не позволяет прояснить ключевые этапы патогенеза аутоиммунных заболеваний щитовидной железы и, следовательно, применить таргетные способы лечения этих заболеваний. Детальное изучение роли клеток врожденного и адаптивного иммунитета в нарушении толерантности к аутоантигенам щитовидной железы при болезни Грейвса и аутоиммунном тиреоидите прояснит и подготовит ряд теоретических основ для создания в перспективе клинико-иммунологического мониторинга и прогнозирования этих заболеваний.

Precise mechanisms of tolerance loss to thyroid auto-antigens are still largely unknown, thus preventing further elucidation of key pathogenetic stages in autoimmune diseases affecting thyroid gland, and, therefore, to identify target pathways for treatment of these disorders. Detailed studies on the role of innate and adaptive immune cells in disturbed tolerance to autoantigens specific for thyroid gland in Graves’ disease and autoimmune Hashimoto’s thyroiditis have revealed and provided a number of theoretical foundations for arrangement of clinical immunological monitoring and forecasting of these diseases in a long-term prospective.

аутоантигенытолерантностьтиреоцитаутоантителамастоцитцитокины

self-antigenstolerancethyrocytesautoantibodiesmast cellcytokines

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The authors declare that there are no conflicts of interest present.