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Медицинская иммунология

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ИММУНОТЕРАПИЯ ОПУХОЛЕЙ, ОСНОВАННАЯ НА БЛОКИРОВКЕ ИММУНОЛОГИЧЕСКИХ КОНТРОЛЬНЫХ «ТОЧЕК» («ЧЕКПОЙНТОВ»)

https://doi.org/10.15789/1563-0625-2015-5-395-406

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Аннотация

Иммунологические контрольные «точки» (ИКТ, англ. Immunological checkpoints) – это система ингибиторных механизмов, которые регулируют активацию иммунного ответа, препятствуя запуску аутоиммунных процессов, а также модулируют его, уменьшая вызванные иммунными клетками повреждения в органах и тканях. Опухолевые клетки могут использовать такие контрольные точки для предотвращения активации опухоль-специфических лимфоцитов, таким образом, приобретая устойчивость к действию иммунной системы. Одним из перспективных методов иммунотерапии опухолей является блокировка ингибирующего сигнала, передающегося через иммунологические контрольные точки, приводящая к реактивации противоопухолевого иммунного ответа. Поскольку большая часть контрольных точек функционирует за счет взаимодействий лиганд-рецептор, одна из стратегий современной противоопухолевой терапии основана на создании терапевтических моноклональных антител, блокирующих лиганд или рецептор, а также растворимых рекомбинантных рецепторов, которые могли бы конкурировать за лиганд и таким образом модулировать передачу сигнала. В последние годы в этом направлении иммунотерапии опухолей получены впечатляющие успехи, однако потенциальной платой за вмешательство в естественные супрессорные механизмы является развитие аутоиммунных реакций.

Об авторах

А. В. Боголюбова
Институт молекулярной биологии им. В.А. Энгельгардта, Москва; Московский государственный университет им. М.В. Ломоносова
Россия

Младший научный сотрудник, лаборатория молекулярных механизмов иммунитета ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН; кафедра иммунологии, биологический факультет, ФГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»:

Адрес для переписки: Боголюбова Аполлинария Васильевна ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН 119991, Россия, Москва, ул. Вавилова, 32. Тел.: 8 (499) 135-99-64. Факс: 8 (499) 135-14-05. E-mail: apollinariya.bogolyubova@gmail.com



Г. А. Ефимов
Институт молекулярной биологии им. В.А. Энгельгардта, Москва; Гематологический научный центр, Москва
Россия
Кандидат биологических наук, заведующий лабораторией трансплантационной иммунологии, ФГБУ «Гематологический научный центр» Министерства здравоохранения РФ; лаборатория молекулярных механизмов иммунитета ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН


М. С. Друцкая
Институт молекулярной биологии им. В.А. Энгельгардта, Москва
Россия
Кандидат биологических наук, старший научный сотрудник лаборатории молекулярных механизмов иммунитета, ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН


С. А. Недоспасов
Институт молекулярной биологии им. В.А. Энгельгардта, Москва; Московский государственный университет им. М.В. Ломоносова
Россия
Доктор биологических наук, профессор, заведующий лабораторией молекулярных механизмов иммунитета ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН; кафедра иммунологии, биологический факультет, ФГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»


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Для цитирования:


Боголюбова А.В., Ефимов Г.А., Друцкая М.С., Недоспасов С.А. ИММУНОТЕРАПИЯ ОПУХОЛЕЙ, ОСНОВАННАЯ НА БЛОКИРОВКЕ ИММУНОЛОГИЧЕСКИХ КОНТРОЛЬНЫХ «ТОЧЕК» («ЧЕКПОЙНТОВ»). Медицинская иммунология. 2015;17(5):395-406. https://doi.org/10.15789/1563-0625-2015-5-395-406

For citation:


Bogolyubova A.V., Efimov G.A., Drutskaya M.S., Nedospasov S.A. CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS. Medical Immunology (Russia). 2015;17(5):395-406. (In Russ.) https://doi.org/10.15789/1563-0625-2015-5-395-406

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